目的建立运用液相色谱-串联质谱法同时测定参甘冠心合剂中11种成分(芍药苷、毛蕊花糖苷、阿魏酸、柚皮苷、丹酚酸B、党参炔苷、橙皮苷、甘草苷、异甘草苷、甘草素、异甘草素)含量的分析方法。方法采用AgilentSB-C₁₈柱(2.1mm×50mm，1.8μm)色谱柱;流动相:0.1%甲酸水-0.1%甲酸甲醇梯度洗脱;流速:0.3mL·min^-1;柱温:室温;采用电喷雾离子源(ESI)，多反应监测扫描模式(MRM)进行定量分析。结果芍药苷、毛蕊花糖苷、阿魏酸、柚皮苷、丹酚酸B、党参炔苷、橙皮苷、甘草苷、异甘草苷、甘草素、异甘草素分别在0.7580~30.32μg·mL^-1(r=0.9949)、0.3040~12.16μg·mL^-1(r=0.9995)、0.2480~9.920μg·mL^-1(r=0.9969)、0.5035~20.14μg·mL^-1(r=0.9983)、0.9100~36.40μg·mL^-1(r=0.9994)、0.0975~3.900μg·mL^-1(r=0.9989)、0.9965~39.86μg·mL^-1(r=0.9982)、0.2535~10.14μg·mL^-1(r=0.9975)、0.2480~9.920μg·mL^-1(r=0.9967)、0.2770~11.08μg·mL^-1(r=0.9950)、0.1530~6.120μg·mL^-1(r=0.9928)，线性关系良好;平均加样回收率(n=6)均在98.47%~101.91%内，RSD均小于2.5%。结论本法简便、快速、灵敏、准确，可为参甘冠心合剂的质量控制提供依据。

OBJECTIVE To establish an LC-MS/MS method to determine eleven components(paeoniflorin,acteoside,ferulic acid,naringin,salvianolic acid B,lobetyolin,hesperidin,liquiritin,isoliquiritoside,liquiritigenin,isoliquiritigenin) in Shengan Guanxin Mixture(traditional Chinese medicines) simultaneously. METHODS The HPLC analysis was performed on an Agilent SB-C₁₈ column(2.1 mm×50 mm,1.8 μm) with gradient elution of 0.1% formic acid and methanol containing 0.1% formic acid,the flow rate was 0.3 mL·min^-1,and the column temperature was room temperature. Electrospray ionization(ESI) source was used. Quantitation was performed by using selected multiple reaction monitoring(MRM) mode. RESULTS The method had good linearity in the ranges of 0.758 0-30.32 μg·mL^-1(r=0.994 9) for paeoniflorin,0.304 0-12.16 μg·mL^-1(r=0.999 5) for acteoside,0.248 0-9.920 μg·mL^-1(r=0.996 9) for ferulic acid,0.503 5-20.14 μg·mL^-1(r=0.998 3) for naringin,0.910 0-36.40 μg·mL^-1(r=0.999 4) for salvianolic acid B,0.097 5-3.900 μg·mL^-1(r=0.998 9) for lobetyolin,0.996 5-39.86 μg·mL^-1(r=0.998 2) for hesperidin,0.253 5-10.14 μg·mL^-1(r=0.997 5) for liquiritin,0.248 0-9.920 μg·mL^-1(r=0.996 7) for isoliquiritoside,0.277 0-11.08 μg·mL^-1(r=0.995 0) for liquiritigenin,and 0.153 0-6.120 μg·mL^-1(r=0.992 8) for isoliquiritigenin. The average recoveries of the eleven active components were 98.47%-101.91% with RSDs of less than 2.5%(n=6). CONCLUSION The method is convenient,rapid,sensitive and reliable.It may provide a basis for the quality control of Shengan Guanxin Mixture.